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Oleo Shines at Mary Jane Berlin Event

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Mary Jane Berlin provided the perfect stage for Oleo to unveil its ground breaking product, capturing the attention of attendees and industry experts alike. A Global Stage of Innovation with more than 250 exhibitors from around the world. Mary Jane Berlin is undeniably the pinnacle of industry trade fairs. Oleo proudly stood among these innovative companies, showcasing our passion for advancing medical cannabis solutions. Our presence illuminated the diverse landscape of cannabis offerings, from start-ups with fresh ideas to established giants shaping the industry’s future.

Spotlight on Innovation

At Mary Jane Berlin, it’s not just about showcasing products; it’s a platform for sharing knowledge and sparking meaningful discussions. Oleo took this opportunity to connect with renowned national and international hemp experts, engaging in conversations that delved deep into the nuances of the industry. These discussions enriched our understanding and fuelled our commitment to pushing the boundaries of medical cannabis.

Our standout product, the medical cannabis inhaler/vape, captured the attention and imagination of the event’s attendees. Designed to provide a controlled and convenient method of medical cannabis consumption. It’s a testament to Oleo’s dedication to patient-centric innovation, and what truly sets this product apart is the integration of cutting-edge tracking technology.

By incorporating a connection that enables attending doctors to monitor consumption frequency and quantity, we’ve elevated the level of patient care and safety. This technology empowers medical professionals to ensure that patients adhere to prescribed doses while offering a mechanism to prevent misuse. The ability to remotely deactivate the device if the maximum prescribed dosage is exceeded shows our commitment to responsible usage and patient well-being.

Celebrating on the Banks of the Spree

Beyond the business aspect, Mary Jane Berlin offered a festive celebration of cannabis culture. Situated along the banks of the Spree River, the event’s location provided a picturesque backdrop for attendees to immerse themselves in the experience. Oleo was thrilled to contribute to this atmosphere by showcasing our innovation and joining in the spirit of celebration.

Looking Forward

As Oleo, we’re honoured to have been part of the Mary Jane Berlin event that unites the global cannabis community. The recognition and interest generated by our medical cannabis inhaler/vape serve as a testament to the dedication and hard work of our team. With every event, we’re not only showcasing our products but also sharing our vision for the future of medical cannabis. Read more about Oleo’s participation in the Yippy Green feature.

Oleo team @ Mary Jane
Oleo at Mary Jane, Berlin 2023
Medical marijuana and cancer

Medical Marijuana and Cancer

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You may be wondering about Medical Cannabis and Cancer. Medical cannabis is increasingly being used to treat the symptoms of cancer. Cannabis has been found to be an effective way to reduce pain, nausea, and vomiting associated with chemotherapy and other treatments. Additionally, cannabis use has also been found to reduce anxiety and depression in cancer patients. Research has also suggested that cannabis can have a positive effect on some of the side effects caused by radiation therapy and even slow down the progression of certain types of cancers. With further research and clinical trials, medical cannabis may pave the way for more successful treatments for cancer in the future

What is Medical Cannabis?

Medical cannabis is a broad term for cannabis-based medicine that is used to relieve symptoms of certain conditions. The cannabis plant contains more than 100 different chemicals named cannabinoids, with each one producing a different effect on the endocannabinoid system in the body. Delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two main cannabinoids used in medicinal cannabis in Ireland. Medical cannabis is available to treat chemotherapy-induced nausea and vomiting (CINV). 

Read more about Medical Cannabis here.

Cannabis Oil, CBD Oil, Hemp Oil

Cannabis Oil comes from the flowers, leaves, and stalks of the cannabis plant. Cannabis Oil often contains high levels of Tetrahydrocannabinol (THC). Cannabis Oil is only available under prescription. 

CBD Oil comes from the flowers of the cannabis plant and does not contain high levels of Tetrahydrocannabinol (THC), one of the many cannabinoids in cannabis. CBD Oil is often sold in health shops as a food supplement. CBD is approved as a treatment for other medical conditions such as Epilepsy, but no CBD products have been approved for use to treat chemotherapy-induced nausea and vomiting. 

Hemp Oil comes from the seeds of the cannabis plant, these seeds do not contain any Tetrahydrocannabinol (THC).

An Overview of Cannabis Research for Cancer

Up to three-fourths of all cancer patients experience chemotherapy-induced nausea and vomiting. CINV can complicate or prevent the administration of planned therapy, decrease the quality of life, and can often be the most distressing and feared consequence of chemotherapy, effective management is essential. 

A trial was conducted by the University of Sydney on behalf of the New South Wales Government in 2020. The trial ran for 2 and a half years with a total of 81 patients enrolled. Patients received capsules containing 2.5 mg THC and 2.5 mg CBD, which increased to 5mg over the course of the trial. Results showed significant improvement in nausea and vomiting from chemotherapy. Side effects such as sedation, dizziness and drowsiness were rated as moderate in about one-third of people using medicinal cannabis, but these are considered manageable.

The authors of this study plan to continue this research with a phase 3 parallel component of this trial, recruiting 170 CINV patients.

Smith et al conducted a review in 2015 titled “Cannabinoids for Nausea and Vomiting in adults with cancer receiving chemotherapy”. Smith reviewed 23 controlled trials examining the quality of evidence for cannabis-based medicines on cancer symptoms such as nausea and vomiting. The review found that people who received medical cannabis for symptoms experienced less nausea and vomiting. It found participants who received cannabinoids were five times as likely to report a complete absence of vomiting, and three times as likely to report a complete absence of nausea and vomiting.

Tramèr , Carroll et al systematically reviewed cannabinoids for control of chemotherapy-induced nausea and vomiting. The evidence we have from randomised trials shows cannabinoids to be slightly better than conventional antiemetics for treating chemotherapy-induced nausea and vomiting. Additionally, patients preferred cannabis-based medicine. In selected patients, cannabinoids may be useful as mood-enhancing adjuvants for the control of chemotherapy-related sickness.

How does a person qualify for the use of Medical Cannabis?

The programme makes it possible for a consultant to prescribe medicinal cannabis for a number of conditions, where a patient has failed to respond to traditional pharmaceutical treatments.
Currently, three conditions qualify under the Medicinal Cannabis Access Programme.

You can take our eligibility checker to see if you are eligible to qualify for the Medical Cannabis Access Programme. 

Medical Cannabis Access Programme

In June 2019 the Minister for Health launched the Medical Cannabis Access Programme to be operational on a pilot basis for five years. The programme will help facilitate access to medicinal cannabis for suitable candidates. The Medicinal Cannabis Access Programme is currently under review by the Department of Health

The program allows a consultant to prescribe medicinal cannabis for a variety of diseases in which a patient has not responded to typical pharmaceutical therapies.

The Medicinal Cannabis Access Programme now accepts three conditions.

  • Multiple sclerosis-related spasticity
  • Symptoms of chemotherapy-induced nausea and vomiting
  • Severe, refractory (unresponsive to therapy) epilepsy

    The Department of Health is currently reviewing the Medicinal Cannabis Access Programme.Learn More regarding the following Conditions Below:

    Register as a Patient Today.

How does Cannabis help treat Cancer Related Symptoms?

Nausea and vomiting due to chemotherapy are common side effects of treatment. Medical cannabis for cancer patients has been shown to alleviate these symptoms. Considerable evidence demonstrates that manipulation of the endocannabinoid system regulates nausea and vomiting in humans. According to randomised research, medicinal cannabis is more effective than traditional medication for treating nausea and vomiting due to chemotherapy.

Methods of Consumption

Depending on the medical marijuana product you are prescribed there are multiple ways to administer medicinal cannabis.

  • Inhalation: Inhaled cannabis may be the most well-known method of administration for medical cannabis flowers. The main benefit of inhaled cannabis is that the onset of action is practically quick, making it simple for a patient to titrate the dosage for maximal benefit. At Oleo we have developed our Panacea Inhaler which is available to patients prescribed medical cannabis under the Medical Cannabis Access Programme and is also available to buy on Amazon.
  • Sublingual: Sublingual delivery is another option for the administration of oil-based medical cannabis. Medical cannabis oil can have a rapid onset of action by being administered under the tongue or in the oral cavity. The patient feels the effects after a few minutes. Other cannabis products may come in a spray bottle that can be sprayed directly into the mouth.
  • Tablet/ Pill format: Cannabinoids are soluble in fat, their absorption through the gut is slower and less predictable, depending on both the metabolism of the individual and the contents of the stomach. Determining an effective dose is more challenging, especially for the inexperienced patient, because the onset of the effect may take up to an hour to occur.

Are there any side-effects with Medical Marijuana?

Medical cannabis, like all medications, poses a risk of side effects. The type of medical cannabis product, the active chemicals (such as CBD, THC, or a combination), and individual differences can all have a significant impact on side effects. THC-containing products can impair driving and cognitive performance and produce sedation, anxiety, dizziness, appetite stimulation, and other symptoms. Although CBD rarely has significant negative effects on its own, it can change the effects of other prescribed drugs.

Laws Surrounding the Use Of Cannabis

Cannabis containing THC is currently illegal in Ireland. As a medical patient, you may be permitted to obtain a prescription for medical cannabis under either the MCAP programme or a Ministerial Licence.  Cannabis obtained without a prescription remains illegal under the Misuse of Drugs Act 1977.

You can view our blog  Is Cannabis Legal in Ireland to find out more. 

Conclusion

There are multiple sources of evidence to show that cannabis can be effective in managing symptoms and treatment side effects of cancer such as nausea and vomiting. Unfortunately, most cancer patients receiving chemotherapy will suffer from its side effects. When patients do not respond to routine medication to control nausea and vomiting medical cannabis may be prescribed. It is best to discuss medical cannabis with your healthcare provider. 

Cannabis & Multiple Sclerosis 

Medical Cannabis and Multiple Sclerosis

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Medical Cannabis and Multiple Sclerosis is one of the most talked about topics. Multiple Sclerosis (MS) is a condition that affects the brain and spinal cord and results in a wide variety of symptoms such as issues with vision, arm or leg movement, sensation, pain and balance. Multiple Sclerosis is a lifelong condition, and, in many cases, it is possible to treat the symptoms. 

What is Medical Cannabis?

There is evidence to suggest medical cannabis can be helpful in the management of chronic pain, including neuropathic pain; spasticity; nausea and vomiting, particularly in the context of chemotherapy; and in the management of anxiety. Patients with Multiple Sclerosis have found relief from their symptoms and a reduction in pain through medical cannabis treatment. 

Read more about Medical Cannabis here.

An Overview of Cannabis Research for Multiple Sclerosis 

60-84% of multiple sclerosis patients experience spasticity. When severe, it can be extremely challenging in terms of mobility. Studies have shown that cannabis treatment for multiple sclerosis can show an improvement in spasticity measures in over half of the patients treated. 

A study titled the Multiple Sclerosis and Extract of Cannabis study (MUSEC) conducted in the UK by Zajicek et al showed the benefits of cannabis and cannabinoids in patients with multiple sclerosis. The study was conducted on 277 patients with Multiple Sclerosis and saw patients given 2.5mg of Tetrahydrocannabinol (THC) and revised upwards to a maximum of 25mg for up to 12 days. This study showed the relief from muscle stiffness for those people taking the medical cannabis extract was “almost twice as high than with placebo. 

A controlled trial of cannabis-based medicines for spasticity relating to Multiple Sclerosis was conducted in the UK in 2007 by Collin, Davis et al. The study used whole-plant cannabis-based medicine containing Δ-9 tetrahydrocannabinol (THC) and cannabidiol (CBD) in 189 patients. Over 6 weeks patients were treated with 2.7 mg of delta-9-tetrahydrocannabinol (THC) and 2.5mg of cannabidiol (CBD). Patients illustrated a 30% reduction in spasticity over the course of the trial. Patients also showed an increase in muscle power in the legs, suggesting a reduction in spasticity was not gained at the cost of increasing weakness. 

In 2022 Haddad , Dokmak and Karaman reviewed the Efficacy of Cannabis on Multiple Sclerosis -Related Symptoms. They reviewed a number of symptoms such as Spasticity, MS-Related Pain , MS-Related Tremor and Ataxia, Bladder dysfunction and quality of life of MS patients. The study found that medical cannabis was successful in treating pain and spasticity which are the most common symptoms in Multiple Sclerosis patients. 

Medical Cannabis Access Programme

In June 2019 the Minister for Health launched the Medical Cannabis Access Programme to be operational on a pilot basis for five years. The programme will help facilitate access to medicinal cannabis for suitable candidates.

The programme makes it possible for a consultant to prescribe medicinal cannabis for a number of conditions, where a patient has failed to respond to traditional pharmaceutical treatments.
Currently, three conditions qualify under the Medicinal Cannabis Access Programme.

The Medicinal Cannabis Access Programme is currently under review by the Department of Health.

If you wish to learn more in detail about the following conditions, please check out our blogs below:

Register as a Patient Today.

How could Medical Marijuana help with Multiple Sclerosis ?

A study from the University of Rochester MS Centre in New York looked at the “real world” experience of medical cannabis in managing symptoms of multiple sclerosis. 77% said medical cannabis was helpful in managing their symptoms, mainly spasticity and pain.  A further 70% felt their quality of life improved. The Rochester study concluded that medical cannabis appears to have a role in managing the symptoms of MS through direct symptom relief and reduction in other medications.

What is THC?

THC, known by its scientific name, Tetrahydrocannabinol is the principal psychoactive constituent of cannabis and one of at least 113 total cannabinoids identified on the plant.

CBD Vs THC 

CBD, also known as Cannabidiol, is the second most common cannabinoid found in the cannabis plant. CBD does not produce any psychoactive effect.

Both CBD and THC are chemically similar to your body’s endocannabinoids. This allows them to interact with your cannabinoid receptors. Although CBD Oil and THC have similar chemical structures, they don’t both have the same psychoactive properties. While CBD is psychotropic, it does so differently than THC. It doesn’t result in a THC-related high. The brain’s cannabinoid 1 (CB1) receptors bind with THC. It results in a high or euphoric feeling. According to research, this high can be more intense if the THC is inhaled as opposed to consuming.

Different Methods to take Medical Cannabis 

Depending on the medical cannabis product you are prescribed there are multiple ways to administer medicinal cannabis.

  • Inhalation: Inhaled cannabis may be the most well-known method of administration for medical cannabis flowers. The main benefit of inhaled cannabis is that the onset of action is practically quick, making it simple for a patient to titrate the dosage for maximal benefit. At Oleo we have developed our Panacea Inhaler which is available to patients prescribed medical cannabis under the Medical Cannabis Access Programme and is also available to buy on Amazon.
  • Sublingual: Sublingual delivery is another option for the administration of oil-based medical cannabis. Medical cannabis oil can have a rapid onset of action by being administered under the tongue or in the oral cavity. The patient feels the effects after a few minutes. Other cannabis products may come in a spray bottle that can be sprayed directly into the mouth.
  • Tablet/ Pill format: Cannabinoids are soluble in fat, their absorption through the gut is slower and less predictable, depending on both the metabolism of the individual and the contents of the stomach. Determining an effective dose is more challenging, especially for the inexperienced patient, because the onset of the effect may take up to an hour to occur.

Are there any side effects to watch out for? 

The most frequent negative effects of cannabis are related to the THC content and include nausea, drowsiness, and dizziness. Depending on the particular product, they may occur to varying degrees, but in general, these adverse effects are self-limiting and frequently manageable.

Patients often worry about their driving ability, which can be affected by cognitive side effects of medications as well as by symptoms such as weakness and spasticity. A recent review of medical cannabis showed no detrimental effect on driving; indeed, some patients report improved driving ability, possibly due to reduced spasticity and spasms. Patients should be counselled that using cannabinoids may affect their ability to drive and they should monitor any cognitive symptoms.

Is cannabis legal in Ireland? 

Prescribed medical cannabis is legal in Ireland. Cannabis obtained without a valid prescription will fall under the Misuse of Drugs Act 1977 and will be deemed illegal. Recreational cannabis is illegal in Ireland. You can view a breakdown of the laws relating to illegal cannabis here.

Read our similar blog on: Is Medical Cannabis Legal in Ireland

Conclusion 

Medical cannabis and multiple sclerosis have a successful relationship. It has proven to be an effective weapon in the treatment of MS. Patients have reported a reduction in symptoms and increased muscle strength due to medical cannabis. If you suffer from spasticity due to Multiple Sclerosis, take our eligibility checker to see if you can avail of medical cannabis, or discuss medical cannabis with your healthcare provider.

cannabis & epilepsy

Medical Marijuana and Epilepsy

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Does Medical Cannabis & Epilepsy go together? Epilepsy Ireland describes epilepsy as a neurological disorder which affects the brain. It is a tendency to have repeated seizures. This tendency can be long term, but the seizures can be controlled meaning that a person can have epilepsy but may not have active seizures. Seizures can start in a part of the brain or happen on both sides of the brain at once. Approximately one-third of patients with epilepsy have seizures that are resistant to antiepileptic medications.

https://www.epilepsy.ie/content/epilepsy-explained

What is Medical Cannabis?

Medical cannabis is a broad term for cannabis-based medicine that is used to relieve symptoms of certain conditions. The cannabis plant contains more than 100 different chemicals named cannabinoids, with each one producing a different effect on the endocannabinoid system in the body. Delta-9 tetrahydrocannabinol (THC) and cannabidiol (CBD) are the two main cannabinoids used in medicinal cannabis in Ireland. Medical cannabis and epilepsy have a long history, with some evidence to suggest it was used in medieval times as a treatment. Medical cannabis is available in Ireland for treatment-resistant epilepsy. 

You can find out all about Medical Cannabis here.

An Overview of Cannabis & Epilepsy Research

One of the first successful trials for cannabis and epilepsy was conducted in 1978 by Mechoulam and Carlini. Patients were given 200mg of CBD daily for three months. The findings of the study show that half of the patients had no seizures during the three months of the trial, with no side effects reported. 

In 1980 Cunha et al conducted a further study on the relationship between cannabis and epilepsy. Patients were given 20-300mg of CBD daily for up to 18 weeks. Half of the patients remained seizure-free during the trial, with the remainder of patients finding they had a partial improvement in their symptoms. 

In 2016 Devinsky focussed on the treatment-resistant condition Dravet Syndrome. Dravet syndrome is a complex childhood epilepsy disorder that is associated with drug-resistant seizures and a high mortality rate. 120 children and young adults were part of this trial and received CBD Oil for epilepsy at a dose of 20 mg per kilogram of body weight per day. The study concluded that among patients with Dravet syndrome, cannabidiol resulted in a reduction in convulsive-seizure frequency, with 5 % becoming seizure-free. 

There are many forms of treatment-resistant epilepsy that can be helped with medical cannabis. Lennox-Gastaut Syndrome is a rare form of epilepsy that affects 2 per 100,000 people. Affected children experience several different types of seizures most commonly atonic, tonic, and atypical absence seizures. Children with Lennox-Gastaut syndrome may also develop cognitive dysfunction, delays in reaching developmental milestones and behavioural problems. Lennox-Gastaut syndrome can be difficult to treat because it is resistant (refractory) to many kinds of antiseizure medications. Devinsky enrolled 225 patients to receive cannabidiol oral solution at a dose of either 20 mg or 10 mg per kilogram of body weight or a placebo over the course of 14 weeks. The study showed those receiving 10 or 20 mg doses had a reduction in the frequency of seizures vs. the placebo group. The study concluded that among children and adults with Lennox-Gastaut syndrome cannabis, in particular, CBD oil was effective at reducing seizure frequency in the treatment of epilepsy. 

How does a person qualify for the use of Medical Cannabis? 

To qualify for the Medical Cannabis Access Programme for cannabis treatment for epilepsy, a person must suffer from severe, refractory (treatment-resistant) epilepsy. A patient will be permitted to access cannabis treatment for epilepsy when the patient has failed to respond to standard treatment.  You can take our eligibility checker to see if you are eligible to qualify for the Medical Cannabis Access Programme. 

Medical Cannabis Access Programme 

On 26th June 2019, the Minister for Health signed legislation to allow for the operation of the Medical Cannabis Access Programme (MCAP) on a pilot basis for five years.

The MCAP enables a medical consultant to prescribe a cannabis-based treatment for a patient under his or her care for the following medical conditions, where the patient has failed to respond to standard treatments:

You can read all about the Medical Cannabis Access Programme here.

Learn More regarding the following Conditions Below:

Register as a Patient Today.

Types of Epilepsy 

Epilepsy can be classified into four main categories: focal, generalised, combined focal and generalised, and unknown. If a patient experiences two or more unexplained seizures, a doctor will typically make the diagnosis of epilepsy.

The majority of individuals with epilepsy receive medication, and as a result, two-thirds of them live seizure-free lives. For one-third of adults, medication is ineffective in managing their seizures. Although it is rare for epilepsy to go away on its own, seizures can be controlled with the right treatment. Epilepsy does not have to prevent you from leading a normal, fulfilling life.

Marijuana and Epilepsy 

According to the research, Tetrahydrocannabinol (THC), the most well-known active component of cannabis, is just one of a number of compounds that have been found to have medical properties. Cannabidiol (CBD), another compound non-psychoactive, is becoming one of the most well-known compounds in the treatment of epilepsy. 

How does THC affect people with Epilepsy? 

Both THC and CBD are in a group of substances called cannabinoids. They bind to receptors in the brain and are effective at managing conditions such as epilepsy and multiple sclerosis. While there is a mounting consensus among people with epilepsy that medicinal cannabis is effective, like all medications there can be side effects. 

CBD for Epilepsy 

Beyond seizure management alone, CBD medicines have the potential to address problems of the nervous system that cause seizures. According to the studies above, CBD has resulted in patients becoming seizure-free or drastically reducing the frequency of seizures leading them to live a full and normal life.  

How to take Cannabis for Epilepsy 

Working with a doctor when using medical cannabis to treat seizures is very important. Your doctor can help determine if medical cannabis will interact with any of your current medications and if it best suits your condition. 

Are there any side effects? 

Side effects might also depend on how the drug is taken. Smoking it would pose a risk to the lungs while eating it would not. Talk to your doctor if you are suffering from epileptic seizures and are not responding to traditional treatments. They can explain your options and provide information about medical cannabis treatment for epilepsy. The most common side effects of CBD include:

  • sleepiness
  • drowsiness
  • diarrhoea
  • loss of appetite

Is Medical Cannabis legal? 

Medical cannabis is available for treatment-resistant epilepsy under the Medical Cannabis Access Programme. You may be open to prosecution if you obtain cannabis without a valid prescription. 

Read more on: Is Medical Cannabis Legal in Ireland

Conclusion 

Medical cannabis and epilepsy have a long history together. In more recent years research has unlocked its potential as an epilepsy treatment. Studies have shown medical cannabis can result in patients living seizure free life, or drastically reducing their seizures resulting in a better quality of life.  If you suffer from treatment-resistant epilepsy you may qualify for medical cannabis under the MCAP programme. 

Medical Cannabis Access Programe

Dublin man becomes first patient in Ireland to be prescribed medicinal cannabis

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In November 2021, Ryan Gorman (26) was the first patient in Ireland to be granted a prescription for medical cannabis through the Medical Cannabis Access Programme (MCAP).  Ryan has an aggressive form of epilepsy as well as Autism Spectrum Disorder.  He received the high CBD, low THC formula which is approved by the Primary Care Reimbursement Service (PCRS), making it free of charge.

Ryan’s father and full-time carer, Brendan Gorman spoke with BusinessCann and shared his joy on this major milestone:

“For those people out there that have been waiting so anxiously to see when I’m gonna get access to it, finally the day has arrived. It can only be described as wonderful news, and hopefully, the benefits will be there for everybody,” he said.

“It’s not about being first or being last or in the middle. What is important is that if it becomes accessible, and the barriers are broken down, it’s almost like the Berlin Wall, one goes through then the rest will follow.”

Health Minster Stephan Donnelly announced in July 2021 that medical consultants can register themselves and their patients to the MCAP through the HSE.  Patients will need to be registered before they can be prescribed cannabis-based products.  Minister Donnelly said when announcing the start of the programme:  “Today is a significant step forward in the ongoing delivery of the MCAP.

“This step forward will greatly assist patients who, under the supervision of their consultant, need to avail of medicinal cannabis products to alleviate the effects of their severe medical conditions.

“I now hope the programme continues to go on and grow and expand further, to best meet the needs of patients and families around Ireland.”

Under MCAP only a consultant can prescribe medical cannabis where conventional treatment has failed.  A poll carried out by Red C on behalf of The Journal early last year found that only 4 per cent of people were opposed to the use of medical cannabis.  Almost 1,000 adults across Ireland took part in the survey,  they weighted to be an accurate profile of the population.

The programme is only available to patients with the following medical conditions: spasticity associated with multiple sclerosis, intractable nausea and vomiting associated with chemotherapy and treatment-resistant epilepsy.

 

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